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Table 1 Combination index (CI) for cell viability in GBM cell line U-87 MG treated with SP600125 and PIK-75, TGX-221 or CAL-101 (n = 3)

From: PI3K p110β isoform synergizes with JNK in the regulation of glioblastoma cell proliferation and migration through Akt and FAK inhibition

PIK-75 (μM)

TGX-221 (μM)

CAL-101 (μM)

SP600125 (μM)

CI a

PIK-75 + SP600125

TGX-221 + SP600125

CAL-101 + SP600125

0.01

2

1

2

1.333 ± 0.169

1.252 ± 0.040

1.614 ± 0.169

0.025

5

2.5

5

1.645 ± 0.082

0.907 ± 0.005

1.263 ± 0.301

0.05

10

5

10

1.595 ± 0.061

0.837 ± 0.001

0.911 ± 0.107

0.1

20

10

20

1.568 ± 0.047

0.855 ± 0.055

0.809 ± 0.018

0.2

40

20

40

2.104 ± 0.103

1.009 ± 0.125

0.700 ± 0.049

  1. aData were presented as mean ± S.E.M. CI <0.9 indicates synergistic effects; CI >1.1 indicates antagonistic effects; CI between 0.9 and 1.1 indicates additive effects