Table 3 Summary of the immunohistochemistry analyses of the xenografts obtained with cancer patients’ serum-treated BRCA1-KO fibroblasts
Cases | Xenograft Phenotype | Differentiation Markers | |
|---|---|---|---|
Case A | Poorly differentiated carcinoma | Synaptophysin Neurofilament | negative negative |
Case B | Poorly differentiated carcinoma | Estrogen receptor Mammoglobin CK7 | negative rare positivity rare positivity |
Case C | Poorly differentiated carcinoma | Chromogranin Synaptophysin | negative rare positivity rare positivity |
Case D | Poorly differentiated carcinoma | Estrogen receptor Mammoglobin CK7 | negative negative rare positivity |
Case F | Poorly differentiated carcinoma | CK5/6 CK34BE12 AE1/AE3 | negative negative Strongly + ve |
Case E | Differentiation toward intestinal adenocarcinoma | CEA CK7 CK20 CDX-2 AE1/AE3 Vimentin | positive negative positive positive positive negative |
Case G | Differentiation toward intestinal adenocarcinoma | CEA CK7 CK20 CDX-2 AE1/AE3 Vimentin | positive negative positive positive positive negative |
Case H | Differentiation toward intestinal adenocarcinoma | CEA CK7 CK20 CDX-2 AE1/AE3 Vimentin | positive negative positive positive positive negative |
Case I | Differentiation toward intestinal adenocarcinoma | CEA CK7 CK20 CDX-2 AE1/AE3 Vimentin | positive negative positive positive positive negative |
Case J | Differentiation toward typical pancreatic ductal adenocarcinoma | CK7 CK19 AE1/AE3 Vimentin | positive positive positive negative |