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Fig. 6 | Journal of Experimental & Clinical Cancer Research

Fig. 6

From: MicroRNA-655-3p functions as a tumor suppressor by regulating ADAM10 and β-catenin pathway in Hepatocellular Carcinoma

Fig. 6

Loss-of function of ADAM10 mimicked impact of miR-655-3p on HCC cell proliferation and metastasis. a, b IHC staining of ADAM10 in HCC and normal liver tissues. d, f The MTT assay analysis of proliferation after Si-ADAM10 or controls transfected in HepG2 and Huh7 cells respectively. e, g Transwell analysis was used to detect the impact of migration and invasion after Si-ADAM10 or controls transfected in HepG2 and Huh7 cells respectively. c The MTT assay analysis of proliferation ability of Huh7 cells after transfected miR-655-3p antagomiR or co-transfected Si-ADAM10 or controls. h Transwell analysis of migration and invasion abilities of Huh7 cells after transfected miR-655-3p antagomiR or co-transfected Si-ADAM10 or controls. Data are mean ± SEM (n = 3). *p < 0.05, and **p < 0.01 compared to controls

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