Fig. 9

FBXW7 is a direct target of miR-155-3p. a The potential binding site for miR-155-3p in 3’UTR of FBXW7 mRNA. b FBXW7 3’-UTR possessing a mutation in the putative miR-155-3p binding site. c The luciferase activity after transfection in BEL-7405-miR-155-3p and its control cells of the indicated 3’-UTR-driven reporter constructs. Reporter plasmids containing no oligonucleotides as a Control, the wild-type 3’UTR region of FBXW7 as a Wild type and the mutant 3’UTR region as a Mutant. d The luciferase activity after transfection in HepG2-anti-miR-155-3p and its control cells of the indicated 3’-UTR-driven reporter constructs. Reporter plasmids containing no oligonucleotides as a Control, the wild-type 3’UTR region of FBXW7 as a Wild type and the mutant 3’UTR region as a Mutant. **P < 0.01, unpaired two-tailed Student’s t-test