Table 1 MicroRNAs involved in Innate and Adaptive Immune System Functions
From: Targeting microRNAs as key modulators of tumor immune response
| Cell lineage | Cellular process | MicroRNAs | |
|---|---|---|---|
| Immune cell progenitors | |||
| Hematopoietic stem cells | Cell maintenance | let-7ea, miR-29a, miR-99ba, miR-125a, miR-126, miR-212/132 cluster | |
| Multipotent progenitors | Cell development | miR-10 family, miR-126, miR-196b, miR-221/222 | |
| Common myeloid progenitors | Cell development | miR-17, miR-24, miR-126, miR-128, miR-155, miR-181a | |
| Common lymphoid progenitors | Cell development | miR-126, miR-128, miR-146, miR-181a | |
| Granulocyte–macrophage progenitors | Cell development | miR-16, miR-103, miR-107 | |
| Macrophage progenitors | Cell development | miR-17-5p, miR-20a, miR-106a | |
| Granulocyte progenitors | Cell development | miR-223 | |
| Erythroid precursors | Cell development | miR-155, miR-221/222 | |
| Megakaryocyte precursors | Cell development | miR-10a/b, miR-17, miR-20, miR-126 | |
| Innate immunity | |||
| Monocytes | Cell differentiation | miR-17-5p, miR-20a, miR-21, miR-106a, miR-155, miR-196b, miR-223, miR-338, miR-342, miR-424 | |
| Cell activation | miR-155, miR-424 | ||
| Dendritic cells | Cell differentiation | miR-21, miR-34a | |
| Cell function | miR-10a, miR-148/152, miR-155, miR-223 | ||
| Macrophages | Cell differentiation | miR-15a, miR-16, miR-19a-3p, miR-21, miR-107, miR-146a, miR-424 | |
| Cell function | Let-7, miR-9, miR-21, miR-101, miR-125b, miR-146a, miR-147, miR-155, miR-187, miR-212/132 cluster, miR-378, miR-487b, miR-1224 | ||
| Cell polarization | let-7c, let-7f, miR-9, miR-21, miR-33, miR-101, miR-124, miR-125, miR-146, miR-147, miR-155, miR-187, miR-223, miR-342, miR-378, miR-511 | ||
| Granulocytes | Cell differentiation | miR-15a, miR-21, miR-27, miR-196b, miR-223 | |
| Cell function | miR-223 | ||
| Neutrophils | Cell function | miR-223 | |
| MDSCs | Cell function | miR-494, miR-17-5p/20a | |
| Megakaryocytes | Cell differentiation | miR-10a, miR-130a, miR-146a, miR-150, miR-155, miR-223 | |
| Erythrocytes | Cell differentiation | miR-15a, miR-16, miR-24, miR-144, miR-150, miR-155, miR-221/222 cluster, miR-223, miR-451 | |
| Natural killer cells | Cell differentiation | miR-150, miR-181a/b | |
| Cell function | miR-15/16, miR-27a, miR-29, miR-30c-1, miR-30e, miR-155, miR-223, miR-378 | ||
| Adaptive immunity | |||
| B cells | Cell differentiation | miR-17/92 cluster, miR-23a, miR-34a, miR-142, miR-150, miR-155, miR-181 family, miR-212/132 cluster | |
| Cell activation | miR-9, miR-17/92 cluster, miR-30, miR-125b, miR-155, miR-181b, miR-223 | ||
| Plasma cells | Cell differentiation | miR-148a | |
| T cells | Cell differentiation | miR-17/92 cluster, miR-21, miR-142-3p, miR-150, miR-181a, miR-223 | |
| Cell activation | miR-155, miR-181a, miR-182, miR-214 | ||
| T helper cells | Cell differentiation | miR-125b, miR-150 | |
| Cell function | miR-182, miR-214, miR-297, miR-669c | ||
| T helper 1 cells | Cell differentiation | miR-17/92 cluster, miR-29, miR-146a, miR-148a, miR-155, miR-210, miR-326 | |
| T helper 2 cells | Cell differentiation | miR-21, miR-27, miR-28 | |
| Cell function | miR-155 | ||
| T cytotoxic cells | Cell differentiation | Let-7f, miR-15b, miR-16, miR-17/92 cluster, miR-21, miR-139, miR-142, miR-150, miR-155, miR-342 | |
| Cell function | miR-17/92 cluster, miR-21, miR-29, miR-23a, miR-24, miR-27a, miR-30b, miR-130/301, miR-139, miR-146a, miR-150, miR-155, miR-214 | ||
| T regulatory cells | Cell differentiation | miR-17/92 cluster, miR-10, miR-99a/miR-150, miR-155 | |
| Cell function | miR-142-3p, miR-146a, miR-155 | ||
| T helper 17 cells | Cell differentiation | miR-10a, miR-19b, miR-17, miR-155, miR-210, miR-212/132 cluster, miR-301, miR-326 | |
| T follicular helper cells | Cell differentiation | miR-10a, miR-17/92 cluster |