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Fig. 3 | Journal of Experimental & Clinical Cancer Research

Fig. 3

From: Enhanced inhibition of clonogenic survival of human medulloblastoma cells by multimodal treatment with ionizing irradiation, epigenetic modifiers, and differentiation-inducing drugs

Fig. 3

Individual presentation of overall clonogenic survival in D283-Med, MEB-Med8a and DAOY after combined treatment with 5-aza-dC, IR with 2 Gy, and a) VPA, b) SAHA, c) ATRA, d) ABC, e) RES. Cells were treated with 5-aza-dC and a second drug (concentrations are shown in Table 1) for 3 days pre- and 3 days post-IR (2 Gy). Clonogenic survival was examined 10–14 days later. Results after 8 Gy irradiation were similar (Table 2). Data were normalized to the untreated, nonirradiated control (=1) and relative values presented as mean ± SEM from sextuplicates. Statistical significances of treatment groups vs. control (0 or 2 Gy) are indicated by asterisks (*, p ≤ 0.05; **, p ≤ 0.01; ***, p ≤ 0.001) and for combination of all treatments (white bar) vs. 5-aza-dC + control by hash (#, respectively). Additional information about significant synergism/additivity and intergroup significances is given in Table 2

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