Fig. 6

Ectopic expression of TRIM11 impaired the effects of AKT inhibitor on the migration and invasion of lung cancer cells. a, b NCI-H460 and NCI-1975 cells were infected with control virus (Vector) or TRIM11 virus, and migration and invasion assay were performed in the present of either DMSO or AKT inhibitor (MK-2206, 2 μM). MK-2206 was dissolved in DMSO as a 10 mM stock solution. Thus, 0.02 % DMSO was used as negative control. ***P < 0.001 versus Vector + DMSO; ###P < 0.001 versus TRIM11 + DMSO; $$$P < 0.001 versus Vector + MK-2206