|
Kaufman et al. 2009 (TANDEM study)
|
207
|
Anastrozole 1 mg po daily + T iv (4 mg/kg loading dose, then 2 mg/kg weekly)
|
4.8
|
28.5
|
21
|
|
Anastrozole 1 mg po daily
|
2.4 (p = 0.002)
|
23.9 (p = 0.325)
|
7 (p = 0.018)
|
|
Huober et al. 2012 (ELECTRA)
|
92
|
Letrozole 2.5 mg po daily + T iv (4 mg/kg loading dose, then 2 mg/kg weekly)
|
14.1
|
NR
|
27
|
|
Letrozole 2.5 mg po daily
|
3.3 (p = 0.23)
|
NR
|
13 (p = 0.002)
|
|
Johnston et al. 2009 (EGF30008)
|
263
|
Letrozole 2.5 mg po + Lapatinib 1500 mg po daily
|
8.2
|
33.3
|
28
|
|
Letrozole 2.5 mg po + placebo po daily
|
3.0 (p = 0.019)
|
32.3 (p = 0.113)
|
15 (p = 0.021)
|
