Fig. 7

MiR-130b promotes tumor growth and suppresses apoptosis via PPARγ/VEGF-A/BCL-2 signaling in A549 mouse xenograft. a and b Larger tumor volume treated with miR-130b mimic compared with the control at day 30. c MiR-130b mimic decreased PPARγ and apoptosis, but increased VEGF-A and BCL-2 in A549-generated xenografts by immunohistochemistry (upper panels) and TUNEL assay (lower panel). d Quantification analysis of the staining intensity and e the apoptotic rate. f and g MiR-130b mimic decreased the level of PPARγ in A549-generated xenografts, but increased VEGF-A and BCL-2. Scale bar, 50 μm. CTRL: control; TUNEL, terminal deoxynucleotidyl transferase-mediated uridine 5’-triphosphate-biotin nick end labeling. Each bar represents the mean ± SD. Results are representative of three independent experiments. *p < 0.05, #p < 0.001