Fig. 5
From: SYNJ2BP inhibits tumor growth and metastasis by activating DLL4 pathway in hepatocellular carcinoma
Synaptojanin 2 Binding Protein (SYNJ2BP) inhibits HCC tumor growth and metastasis in vivo. The nude mice model was built using Hep3BNC, Hep3BshSYNJ2BP, HCCLM3NC and HCCLM3SYNJ2BP cells. a Orthotopic tumor size in these two groups was calculated and compared. The size of tumors in Hep3BNC and HCCLM3SYNJ2BP groups was significantly smaller than that of Hep3BshSYNJ2BP and HCCLM3NC groups respectively (P < 0.05). b Serial sections of lung from model mice were stained with H&E to identify metastatic nodules, results showed that SYNJ2BP overexpression groups contained fewer(or even none) metastasis nodules than those of their corresponding groups. Original magnification: 400× for (b); pictures from (a) were captured with the aid of a canon camera