Table 3 The Cox proportional hazard regression analysis for disease-free survival

Gender

 Male

14

1

 Female

84

0.618(0.308-1.240)

0.176

n.a.

Age (years)

 >60

27

1

 ≤60

71

0.589(0.342-1.011)

0.055

n.a.

Hepatitis B status

 Negative

17

1

 Positive

81

0.649(0.367-1.145)

0.135

n.a.

AFP(ng/ml)

 ≥20

70

1

 <20

28

0.719(0.448-1.156)

0.173

n.a.

Liver cirrhosis

 Absent

17

1

 Present

81

0.662(0.369-1.188)

0.167

n.a.

Tumor size (cm)

 ≤3

36

1

1

 > 3

62

1.901(1.175-3.074)

0.009

1.663(0.921-3.004)

0.092.

Number of tumors

 Single

47

1

1

 Multiple (≥ 2)

51

1.677 (1.059-2.656)

0.027

0.629(0.337-1.176)

0.147

Vascular invasion

 Absent

45

1

1

 Present

53

2.633(1.625-4.268)

<0.001

2.023(1.679-2.998)

0.031

Child-Pugh classification

 A

76

1

 B

22

1.130 (0.640-1.993)

0.674

n.a.

Edmondson-Steiner grade

 I-II

72

1

 III-IV

26

1.138 (0.692-1.872)

0.611

n.a.

TNM stage

 I/ II

49

1

1

 III

49

1.882(1.440-2.461)

<0.001

1.953(1.163-3.279)

0.011

BCLC

 0-A

54

1

1

 B/C

44

1.776(1.386-2.277)

<0.001

0.941(0.589-1.503)

0.799

SYNJ2BP expression

 Low

39

1

1

 High

59

0.306(0.186-0.506)

<0.001

0.461(0.230-0.927)

0.030