Table 1 Main clinical features according to Nestin status in patients with advance HCC (n = 220)
| Clinical and pathological indexes | Nestin expression | ||||
|---|---|---|---|---|---|
| Total | Low | High | P | ||
| n | n (%) | n (%) | |||
| Age (years) | ≤ 60 | 118 | 52(44.1) | 66(55.9) | 0.119 |
| > 60 | 102 | 54(52.9) | 48(47.1) | ||
| Gender | Male | 109 | 49(45.0) | 60(55.0) | 0.208 |
| Female | 111 | 57(51.4) | 54(48.6) | ||
| HBsAg | Negative | 120 | 59(49.2) | 61(50.8) | 0.427 |
| Positive | 100 | 47(47.0) | 53(53.0) | ||
| Albumin | ≤ 35 g/L | 124 | 57(46.0) | 67(54.0) | 0.498 |
| > 35 g/L | 96 | 49(51.0) | 47(49.0) | ||
| Liver cirrhosis | Absent | 73 | 40(54.8) | 33(45.2) | 0.107 |
| Present | 147 | 66(44.9) | 81(55.1) | ||
| Child-Pugh stage | A | 120 | 57(47.5) | 63(52.5) | 0.466 |
| B | 100 | 49(49.0) | 51(51.0) | ||
| AFP (ng/ml) | ≤ 20 | 77 | 35(45.5) | 42(54.5) | 0.326 |
| > 20 | 143 | 71(49.7) | 72(50.3) | ||
| Edmondson-Steiner grade | I-II | 96 | 52(54.2) | 44(45.8) | 0.077 |
| III-IV | 124 | 54(43.5) | 70(56.5) | ||
| Macroscopic vascular invasion | Absent | 104 | 61(58.7) | 43(41.3) | 0.002 * |
| Present | 116 | 45(38.8) | 71(61.2) | ||
| BCLC stage | B | 86 | 52(60.5) | 34(39.5) | 0.003 * |
| C | 134 | 54(40.3) | 80(59.7) | ||
| Disease status | Confined to the liver | 100 | 57(57.0) | 43(43.0) | 0.012 * |
| Metastatic disease | 120 | 49(40.8) | 71(59.2) | ||