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Table 2 Variables associated with advanced HCC analyzed by a multivariate Cox proportional hazards regression model

From: Nestin overexpression in hepatocellular carcinoma associates with epithelial-mesenchymal transition and chemoresistance

Clinical and pathological variables

PFS

OS

HR

95 % CI

P

HR

95 % CI

P

Age, years

      

(≤ 65 versus > 65)

1.024

0.768–1.366

0.871

1.082

0.818–1.432

0.580

Gender

      

(Male versus Female)

0.877

0.664–1.158

0.356

0.920

0.629–1.224

0.568

HBsAg

      

(Negative versus Positive)

0.961

0.725–1.247

0.781

1.002

0.758–1.325

0.990

Albumin

      

(≤ 35 g/L versus > 35 g/L)

0.974

0.723–1.310

0.859

0.933

0.690–1.262

0.653

Liver cirrhosis

      

(Absence versus Presence)

1.163

0.859–1.574

0.329

0.945

0.701–1.274

0.710

Child-Pugh classification

      

(A versus B)

0.938

0.701–1.255

0.666

0.946

0.710–1.259

0.702

AFP, ng/ml

      

(≤ 20 versus > 20)

0.994

0.723–1.367

0.972

0.824

0.602–1.127

0.227

Edmondson-Steiner grade

      

(I/II versus III/IV)

0.894

0.675–1.183

0.433

1.314

0.985–1.755

0.064

Macroscopic vascular invasion

      

(Absence versus Presence)

1.221

0.885–1.683

0.225

2.023

1.465–2.795

< 0.001 *

BCLC stage

      

(B versus C)

1.892

1.369–2.614

< 0.001 *

1.811

1.340–2.447

< 0.001 *

Disease status

      

(Confined to the liver versus Metastatic disease)

1.118

0.803–1.557

0.508

1.557

1.114–2.176

0.010 *

Nestin expression level

      

(Low versus High)

1.973

1.433–2.716

< 0.001 *

2.375

1.744–3.232

< 0.001 *

  1. Abbreviations: CI confidence interval, HR hazard ratio
  2. *Significant difference is shown in bold