Clinical and pathological variables | PFS | OS | ||||
---|---|---|---|---|---|---|
HR | 95Â % CI | P | HR | 95Â % CI | P | |
Age, years | Â | Â | Â | Â | Â | Â |
(≤ 65 versus > 65) | 1.024 | 0.768–1.366 | 0.871 | 1.082 | 0.818–1.432 | 0.580 |
Gender | Â | Â | Â | Â | Â | Â |
(Male versus Female) | 0.877 | 0.664–1.158 | 0.356 | 0.920 | 0.629–1.224 | 0.568 |
HBsAg | Â | Â | Â | Â | Â | Â |
(Negative versus Positive) | 0.961 | 0.725–1.247 | 0.781 | 1.002 | 0.758–1.325 | 0.990 |
Albumin | Â | Â | Â | Â | Â | Â |
(≤ 35 g/L versus > 35 g/L) | 0.974 | 0.723–1.310 | 0.859 | 0.933 | 0.690–1.262 | 0.653 |
Liver cirrhosis | Â | Â | Â | Â | Â | Â |
(Absence versus Presence) | 1.163 | 0.859–1.574 | 0.329 | 0.945 | 0.701–1.274 | 0.710 |
Child-Pugh classification | Â | Â | Â | Â | Â | Â |
(A versus B) | 0.938 | 0.701–1.255 | 0.666 | 0.946 | 0.710–1.259 | 0.702 |
AFP, ng/ml | Â | Â | Â | Â | Â | Â |
(≤ 20 versus > 20) | 0.994 | 0.723–1.367 | 0.972 | 0.824 | 0.602–1.127 | 0.227 |
Edmondson-Steiner grade | Â | Â | Â | Â | Â | Â |
(I/II versus III/IV) | 0.894 | 0.675–1.183 | 0.433 | 1.314 | 0.985–1.755 | 0.064 |
Macroscopic vascular invasion | Â | Â | Â | Â | Â | Â |
(Absence versus Presence) | 1.221 | 0.885–1.683 | 0.225 | 2.023 | 1.465–2.795 | < 0.001 * |
BCLC stage | Â | Â | Â | Â | Â | Â |
(B versus C) | 1.892 | 1.369–2.614 | < 0.001 * | 1.811 | 1.340–2.447 | < 0.001 * |
Disease status | Â | Â | Â | Â | Â | Â |
(Confined to the liver versus Metastatic disease) | 1.118 | 0.803–1.557 | 0.508 | 1.557 | 1.114–2.176 | 0.010 * |
Nestin expression level | Â | Â | Â | Â | Â | Â |
(Low versus High) | 1.973 | 1.433–2.716 | < 0.001 * | 2.375 | 1.744–3.232 | < 0.001 * |