Skip to main content

Table 2 Variables associated with advanced HCC analyzed by a multivariate Cox proportional hazards regression model

From: Nestin overexpression in hepatocellular carcinoma associates with epithelial-mesenchymal transition and chemoresistance

Clinical and pathological variables PFS OS
HR 95 % CI P HR 95 % CI P
Age, years       
(≤ 65 versus > 65) 1.024 0.768–1.366 0.871 1.082 0.818–1.432 0.580
Gender       
(Male versus Female) 0.877 0.664–1.158 0.356 0.920 0.629–1.224 0.568
HBsAg       
(Negative versus Positive) 0.961 0.725–1.247 0.781 1.002 0.758–1.325 0.990
Albumin       
(≤ 35 g/L versus > 35 g/L) 0.974 0.723–1.310 0.859 0.933 0.690–1.262 0.653
Liver cirrhosis       
(Absence versus Presence) 1.163 0.859–1.574 0.329 0.945 0.701–1.274 0.710
Child-Pugh classification       
(A versus B) 0.938 0.701–1.255 0.666 0.946 0.710–1.259 0.702
AFP, ng/ml       
(≤ 20 versus > 20) 0.994 0.723–1.367 0.972 0.824 0.602–1.127 0.227
Edmondson-Steiner grade       
(I/II versus III/IV) 0.894 0.675–1.183 0.433 1.314 0.985–1.755 0.064
Macroscopic vascular invasion       
(Absence versus Presence) 1.221 0.885–1.683 0.225 2.023 1.465–2.795 < 0.001 *
BCLC stage       
(B versus C) 1.892 1.369–2.614 < 0.001 * 1.811 1.340–2.447 < 0.001 *
Disease status       
(Confined to the liver versus Metastatic disease) 1.118 0.803–1.557 0.508 1.557 1.114–2.176 0.010 *
Nestin expression level       
(Low versus High) 1.973 1.433–2.716 < 0.001 * 2.375 1.744–3.232 < 0.001 *
  1. Abbreviations: CI confidence interval, HR hazard ratio
  2. *Significant difference is shown in bold