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Fig. 1 | Journal of Experimental & Clinical Cancer Research

Fig. 1

From: Evaluation of intraarterial and intravenous cisplatin chemotherapy in the treatment of metastatic osteosarcoma using an orthotopic xenograft mouse model

Fig. 1

Identification of an effective concentration of i.a. CDDP. a Tumor volumes after three separate treatments with 0, 2, or 4 mg/kg of i.a. CDDP. Tumor volumes were determined by caliper measurements. b Presence of pulmonary metastases after treatment with 0, 2, or 4 mg/kg of i.a. CDDP. Metastases on the surfaces of lungs were counted ex vivo after X-gal staining. c Changes in body weight as an indicator for general health of the mice. d Examples of tumor-bearing hind limbs; before the third infusion of i.a. vehicle (upper left) and after the third successful infusion of i.a. vehicle (upper right), 2 mg/kg i.a. CDDP (lower left) and 4 mg/kg CDDP (lower right). The appearance of the blue color across the leg indicated a successful infusion. Days of drug infusion are indicated by black arrows (). *p < 0.05 as compared to the vehicle

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