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Fig. 2 | Journal of Experimental & Clinical Cancer Research

Fig. 2

From: Evaluation of intraarterial and intravenous cisplatin chemotherapy in the treatment of metastatic osteosarcoma using an orthotopic xenograft mouse model

Fig. 2

Effects of different routes of CDDP administration on osteosarcoma development. a Tumor volumes after treatment with vehicle or 4 mg/kg CDDP, both given i.v. and i.a.. Tumor volumes were determined by caliper measurements. Days of drug infusion are indicated by black arrows (). Two-way ANOVA: significant differences are only indicated for day 27. b Representative microCT scans of tumor-bearing bone. White squares mark the areas between the distal end of the patella and the bifurcation of tibia and fibula, which was used for quantification of differences in cortical bone. c Quantitation of differences in cortical (mineralized) bone volume as determined by microCT measurements. d Representative images of X-gal stained lung metastases. White arrowheads (∆) indicate lacZ+ lung metastases. Scale bar corresponds to 500 μm (4X). e Quantitation of number of pulmonary metastases on the entire lung surface. *p < 0.05; **p < 0.01; ***p < 0.001 as compared to the indicated treatment

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