Fig. 3

Changes in hind limb blood perfusion during the treatment period. a Representative images of perfusion measurements of the knee region from each treatment group at the end of the study (27 days post tumor cell injection). Images in the left column illustrate healthy contralateral limbs. Perfusion images in the right column illustrate tumor-bearing limbs. Circular ROIs (only indicated for “i.v. vehicle”) were used for measurements. b Flux-ratios of knee regions during the entire treatment period for individual treatment groups. Labeling of the x-axis indicates the respective measurement times: INF1/2/3: immediately prior to the first/s/third infusion; INF3 + 3d: three days after the final third infusion