Fig. 6

Effects of CDDP treatment on the health of the mice. a Monitoring of body weights during the study as an indicator for general health of the mice. Days of drug/vehicle infusion are indicated by black arrows (). Two-way ANOVA: significant differences are only indicated for day 27. b Quantitation of tubular degeneration at the end of the study. Tubular degeneration is displayed as the median ± the interquartile range. c Apoptotic keratinocyte counts. The number of apoptotic cells per cm of epidermis of the hind limbs was determined. The number of apoptotic keratinocytes was determined in healthy limbs (control limb) as well as tumor-bearing limbs of the same animal. Data points from the same animal are connected. *p < 0.05; ***p < 0.001