Fig. 2
From: Nerve growth factor: role in growth, differentiation and controlling cancer cell development
High levels of exogenous and/or endogenous NGF in tissues without cell proliferation. Illustrations of exogenous NGF-induced trkANGFR expression (a-b) and endogenous NGF expression (c). a Representative brain section from a young rat treated with 1 μg purified NGF into the third brain ventricle. Note the trkANGFR immunreactivity in the dentate gyrus of the hippocampus (arrows). The absence of any sign of cell proliferation within and nearby the hippocampal tissues is clearly visible. b Representative cutaneous tissue section from a mouse exposed to subcutaneous administration of 10 μg purified NGF. An increased trkANGFR immunoreactivity is visible (arrows) in the dermal tissue having no cell proliferation. c Representative submaxillary gland sections from a 10-week-old male-mouse probed with anti-NGF antibody (arrows). Despite the massive NGF immunoreactivity in murine salivary gland (tubular cells; see arrows), no cell proliferation nor cell neoplasy characterized the gland tissue. Magnifications: ab, x100; c, x400, light microscopy