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Fig. 3 | Journal of Experimental & Clinical Cancer Research

Fig. 3

From: Hyperthermia induced HIF-1a expression of lung cancer through AKT and ERK signaling pathways

Fig. 3

Effect of Wortmannin or PD98095 on the proliferation of NSCLC and SCLC following heat treatment. In vitro, the NCI-H1650-b and NCI-H446-b sublines (in logarithmic phase) are treated with wortmannin or PD98095 (40 μM). We compared the growth curve of the cells in control group, wortmannin group, and PD98095 group. a When the NCI-H1650-b subline was treated with wortmannin or PD98095, the growth curve shifted to the right and the growth rate was slowed (* p < 0.05 wortmannin group vs control group, ** p < 0.05 PD98095 group vs control group). b When the NCI-H446-b subline was treated with wortmannin, the growth curve shifted to right and the growth rate was significantly slowed (* p < 0.05 wortmannin group vs control group), but after treatment with PD98095, the growth curve changed very little (** p > 0.05 PD98095 group vs control group). c The growth curve of subcutaneous tumors formed by the NCI-H1650-b subline show that after treatment with wortmannin or PD98095, the curve moved right (* p < 0.05 wortmannin group vs control group, ** p < 0.05 PD98095 group vs control group). d The growth curve of SCLC transplantation tumors shows that treatment with wortmannin but not PD98095 causes the rightward movement of growth curve (* p < 0.05 wortmannin group vs control group, ** p > 0.05 PD98095 group vs control group)

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