Skip to main content
Fig. 5 | Journal of Experimental & Clinical Cancer Research

Fig. 5

From: Induction of the mesenchymal to epithelial transition by demethylation-activated microRNA-125b is involved in the anti-migration/invasion effects of arsenic trioxide on human chondrosarcoma

Fig. 5

ATO induces MET and attenuates the invasive capacities of chondrosarcoma cells through miR-125b. HCS-2/8 cells were transfected with a con-mimic or miR-125b-mimic for 12 h. a qRT-PCR analyses of miR-125b and CDH-1 levels (mean ± SD, n = 3). b Western blot analyses and (c) relative protein levels of E-cadherin, N-cadherin, Slug and MMP9 (mean ± SD, n = 3). **P < 0.01 and *P < 0.05 compared with control cells or cells transfected with con-mimic. After HCS-2/8 cells were transfected by anti-con or anti-miR-125b for 12 h, they were exposed to 1.5 μM ATO for 48 h. d qRT-PCR analyses of miR-125b and CDH-1 levels (mean ± SD, n = 3); e Western blot analyses and (f) relative protein levels of E-cadherin and N-cadherin (mean ± SD, n = 3)

Back to article page