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Fig. 8 | Journal of Experimental & Clinical Cancer Research

Fig. 8

From: Induction of the mesenchymal to epithelial transition by demethylation-activated microRNA-125b is involved in the anti-migration/invasion effects of arsenic trioxide on human chondrosarcoma

Fig. 8

ATO Up-Regulates the Expression of miR-125b and Inhibits Metastasis In Vivo. a Observation of tumors formed by HCS-2/8 cells (left). qRT-PCR analyses of miR-125b, CDH-1 and CDH-2 levels in xenografts (Right) (mean ± SD, n = 3). **P < 0.01 compared with tumors treated with no ATO. b Immunohistochemistry analyses of p-Stat3, E-cadherin, N-cadherin and vimentin levels. c Western blot analyses of p-Stat3, E-cadherin, N-cadherin and vimentin. d Number of metastatic nodules on the surface of the lungs of mice injected with DMSO or ATO is presented. Representative images and H&E staining of lungs on day 70 after the mice were injected with HCS-2/8 cells (n = 6 per group). e Number of metastatic nodules on the surface of the lungs of mice formed by stable anti-miR-125b or anti-con HCS-2/8 cells is presented

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