Fig. 1

p53-MCL in LCLs and in PBMCs from familial breast and/or ovarian BRCA1/2-positive and –negative patients. (a) Comparison of p53-MCL percentages, among LCLs derived from wild type ATM donors (CTR, n = 11), BRCA1/2-negative (n = 7), BRCA1/2-positive (n = 5), CHK2-positive (n = 1), and ATM variants carriers (n = 2) and ATM carriers (n = 9) previously tested. Not significant differences among the groups including wild type ATM (CTR, BRCA1/2-neg, BRCA1/2-pos and CHK2-pos), but significant differences between these groups and ATM carriers groups (ATM variants and ATM carriers). (b) Comparison of p53-MCL percentages among PBMCs from familial breast and/or ovarian BRCA1/2-positive, BRCA1/2–negative and ATM carrier patients. Not significant differences between BRCA1/2-positive and -negative patients, but significant differences between wild type ATM group (BRCA1/2-positive and -negative) and ATM carriers. ***P < 0.0001; NS = Not Significant; 2-tailed Student’s t test