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Table 2 Characteristics of familial breast and/or ovarian cancer patients

From: Detection of ATM germline variants by the p53 mitotic centrosomal localization test in BRCA1/2-negative patients with early-onset breast cancer

Variable Study population n = 90 BRCA1/2 carriers n = 20/90 (22.2 %) ATM carriers n = 5/90(5.5 %)
Age-years
 Median 52.9 53.7 44.4
 Range 30–82 40–75 32–51
Familial aggregation
 HBOC 30 (33.3 %) BRCA1: 8/30 (26 %) 2/30 (6.6 %)
   BRCA2: 4/30 (13 %)  
 HBC 60 (66.7 %) BRCA1: 4/60 (7 %) 3/60 (5 %)
BRCA2: 4/60 (7 %)
BRCAPRO 27.3 % 50.1 % 52.2 %
  1. HBOC hereditary breast and ovarian cancer, HBC hereditary breast cancer