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Table 2 Characteristics of familial breast and/or ovarian cancer patients

From: Detection of ATM germline variants by the p53 mitotic centrosomal localization test in BRCA1/2-negative patients with early-onset breast cancer

Variable

Study population n = 90

BRCA1/2 carriers n = 20/90 (22.2 %)

ATM carriers n = 5/90(5.5 %)

Age-years

 Median

52.9

53.7

44.4

 Range

30–82

40–75

32–51

Familial aggregation

 HBOC

30 (33.3 %)

BRCA1: 8/30 (26 %)

2/30 (6.6 %)

  

BRCA2: 4/30 (13 %)

 

 HBC

60 (66.7 %)

BRCA1: 4/60 (7 %)

3/60 (5 %)

BRCA2: 4/60 (7 %)

BRCAPRO

27.3 %

50.1 %

52.2 %

  1. HBOC hereditary breast and ovarian cancer, HBC hereditary breast cancer