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Table 3 Histopathological characteristics of all cancer patients

From: Detection of ATM germline variants by the p53 mitotic centrosomal localization test in BRCA1/2-negative patients with early-onset breast cancer

Tumor type Cases n = 496 BRCA1/2 carriers n = 20 ATM carriers n = 7
Familial Cancer cases 90 20 5
 Breast 65 (70.6 %) 11/65 (16.9 %) 5/65 (7.7 %)
 Ovarian 8 (8.7 %) 3/8 (37.5 %) 0/8
 Bilateral Breast 10 (10.9 %) 3/10 (30 %) 0/10
 Breast-Ovarian 4 (4.3 %) 2/4 (50 %) 0/4
 Colon-Breast 1 (1.1 %) 0/1 0/1
 Uterin-Breast 1 (1.1 %) 0/1 0/1
 Anal-Bilateral Breast 1 (1.1 %) 0/1 0/1
 Bilateral Breast-Ovarian 1 (1.1 %) 1/1 (100 %) 0/1
 Ipsilateral Breast 1 (1.1 %) 0/1 0/1
Sporadic cancer cases 406 - 2/406
 Ovarian 49 - 0/49
 Lung 150 - 0/150
 Colon 80 - 0/80
 Post-menopausal Breast 58 - 0/58
 Breast/Thyroid 69 - 2/69 (2.9 %)