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Table 3 Histopathological characteristics of all cancer patients

From: Detection of ATM germline variants by the p53 mitotic centrosomal localization test in BRCA1/2-negative patients with early-onset breast cancer

Tumor type

Cases n = 496

BRCA1/2 carriers n = 20

ATM carriers n = 7

Familial Cancer cases

90

20

5

 Breast

65 (70.6 %)

11/65 (16.9 %)

5/65 (7.7 %)

 Ovarian

8 (8.7 %)

3/8 (37.5 %)

0/8

 Bilateral Breast

10 (10.9 %)

3/10 (30 %)

0/10

 Breast-Ovarian

4 (4.3 %)

2/4 (50 %)

0/4

 Colon-Breast

1 (1.1 %)

0/1

0/1

 Uterin-Breast

1 (1.1 %)

0/1

0/1

 Anal-Bilateral Breast

1 (1.1 %)

0/1

0/1

 Bilateral Breast-Ovarian

1 (1.1 %)

1/1 (100 %)

0/1

 Ipsilateral Breast

1 (1.1 %)

0/1

0/1

Sporadic cancer cases

406

-

2/406

 Ovarian

49

-

0/49

 Lung

150

-

0/150

 Colon

80

-

0/80

 Post-menopausal Breast

58

-

0/58

 Breast/Thyroid

69

-

2/69 (2.9 %)