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Table 5 Clinical and pathological characteristics of breast cancer patients of HBOC and HBC

From: Detection of ATM germline variants by the p53 mitotic centrosomal localization test in BRCA1/2-negative patients with early-onset breast cancer

Variable Study population (n = 65) p53-MCL positive (n = 5)
Age-years
 Average 50.4 44.4
 Range 30–82 32–51
Age onset tumor appearance
 Average 42.5 38.6
 Range 24–67 28–43
Diagnosis
 Ductal 47 (72.3 %) 3 (60 %)
 Lobular 8 (12.3 %) 0
 Unknown 8 (12.3 %) 2 (40 %)
 Other 2 (3.1 %) 0
ER status
 Negative 15 (23.1 %) 0
 Positive 36 (55.4 %) 5 (100 %)
 Unknown 14 (21.5 %) 0
PgR status
 Negative 19 (29.2 %) 0
 Positive 32 (49.2 %) 5 (100 %)
 Unknown 14 (21.5 %) 0
HER2 status
 Negative 29 (44.6 %) 4 (80 %)
 Positive 16 (24.6 %) 1 (20 %)
 Unknown 20 (30.8 %) 0
BRCAPRO 32.3 52.2
  1. ER estrogen receptor, PgR progesterone receptor, HER2 human epidermal growth factor receptor 2