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Table 5 Clinical and pathological characteristics of breast cancer patients of HBOC and HBC

From: Detection of ATM germline variants by the p53 mitotic centrosomal localization test in BRCA1/2-negative patients with early-onset breast cancer

Variable

Study population (n = 65)

p53-MCL positive (n = 5)

Age-years

 Average

50.4

44.4

 Range

30–82

32–51

Age onset tumor appearance

 Average

42.5

38.6

 Range

24–67

28–43

Diagnosis

 Ductal

47 (72.3 %)

3 (60 %)

 Lobular

8 (12.3 %)

0

 Unknown

8 (12.3 %)

2 (40 %)

 Other

2 (3.1 %)

0

ER status

 Negative

15 (23.1 %)

0

 Positive

36 (55.4 %)

5 (100 %)

 Unknown

14 (21.5 %)

0

PgR status

 Negative

19 (29.2 %)

0

 Positive

32 (49.2 %)

5 (100 %)

 Unknown

14 (21.5 %)

0

HER2 status

 Negative

29 (44.6 %)

4 (80 %)

 Positive

16 (24.6 %)

1 (20 %)

 Unknown

20 (30.8 %)

0

BRCAPRO

32.3

52.2

  1. ER estrogen receptor, PgR progesterone receptor, HER2 human epidermal growth factor receptor 2