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Fig. 3 | Journal of Experimental & Clinical Cancer Research

Fig. 3

From: Deletion of interleukin-6 in monocytes/macrophages suppresses the initiation of hepatocellular carcinoma in mice

Fig. 3

IL-6 deprivation in monocytes decreases toxic liver injury. a-b Specific loss of IL-6 in monocytes improves liver histology and decreases toxic liver injury. c-d Less macrophage aggregation in liver tissue when their IL-6 was deprived. The numbers of F4/80-positive cells were counted in 10 consecutive high-power fields. Each bar represents the mean ± s.e.m of positive cells in liver sections from three mice. ***p < 0.001. e IL-6 ablation in monocytes suppresses circulating inflammatory factors. Data are presented as mean ± s.e.m, n ≥ 6; **p < 0.01 and ***p < 0.001 between two groups, respectively. Scale bar = 100 μm

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