Fig. 6

Loss of IL-6 in monocytes suppresses tumor growth signaling in mdr2^−/− mice. a The transcription levels of IL-6 mRNA in tumor and non-tumor tissues. b-c Immunoblotting of proteins involved in IL-6 signaling pathway. GAPDH and histone H3 were used as loading control of cytoplasmic protein and nuclear protein, respectively. The levels of the indicated proteins are expressed as ratios to their loading control. Each bar represents the mean ± s.e.m from ≥3 independent experiments. *p < 0.05