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Table 2 List of Genes Associated with Prostate Cancer and Oxidative Stress. [50, 113]

From: Oxidative stress in prostate hyperplasia and carcinogenesis

Gene Gene name Location Papers
KLK3 Kallikrein-related peptidase 3 19q13.41 3000
AR Androgen receptor Xq12 1221
MKI67 Marker of proliferation Ki-67 10q26.2 424
PTEN Phosphatase and tensin homolog 10q23.3 376
TP53 Tumor protein p53 17p13.1 343
TMPRSS2 Transmembrane protease, serine 2 21q22.3 336
CTNNB1 Catenin (cadherin-associated protein), beta 1 3p21 312
BRCA1 Breast cancer 1, early onset 17q21 178
BRCA2 Breast cancer 2, early onset 13q12.3 156
PROC Protein C (inactivator of coagulation factors Va and VIIIa) 2q13-q14 135
CDKN1A Cyclin-dependent kinase inhibitor 1A (p21, Cip1) 6p21.2 125
NKX3-1 NK3 homeobox 1 8p21.2 120
SRD5A2 Steroid-5-alpha-reductase, 2p23 120
SRC SRC proto-oncogene, non-receptor tyrosine kinase 20q12-q13 97
KITLG KIT ligand 12q22 93
CDKN1B Cyclin-dependent kinase inhibitor 1B (p27, Kip1) 12p13.1-p12 92
CD44 CD44 molecule (Indian blood group) 11p13 87
TGFB1 Transforming growth factor, beta 1 19q13.1 83
HIF1A Hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 14q23.2 82
CYP17A1 Cytochrome P450, family 17, subfamily A, polypeptide 1 10q24.3 82
PTGS2 Prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1q25.2-q25.3 81
PPARG Peroxisome proliferator-activated receptor gamma 3p25 81
PCA3 Prostate cancer associated 3 (non-protein coding) 9q21.2 78
IGFBP3 Insulin-like growth factor binding protein 3 7p12.3 76
EZH2 Enhancer of zeste 2 polycomb repressive complex 2 subunit 7q35-q36 75
ETV1 ETS (E twenty-six) variant 1 7p21.3 73
GSTM1 Glutathione S-transferase mu 1 1p13.3 72
JUN Jun proto-oncogene 1p32-p31 65
CAMP Cathelicidin antimicrobial peptide 3p21.3 61
ELAC2 ElaC ribonuclease Z 2 17p11.2 56
SERPINB5 Serpin peptidase inhibitor, clade B (ovalbumin), member 5 18q21.33 54
CD82 CD82 molecule 11p11.2 50
AMACR Alpha-methylacyl-CoA racemase 5p13 50
IGF1R Insulin-like growth factor 1 receptor 15q26.3 49
IL10 Interleukin 10 1q31-q32 47
E2F1 E2F transcription factor 1 20q11.2 46
MSMB Microseminoprotein, beta- (10q11.2) 10q11.2 45
TRPM2 Transient receptor potential cation channel, subfamily M, member 2 21q22.3 44
CYP3A4 Cytochrome P450, family 3, subfamily A, polypeptide 4 7q21.1 43
CLU Clusterin 8p21-p12 43
PSCA Prostate stem cell antigen 8q24.2 42
FOS FBJ murine osteosarcoma viral oncogene homolog 14q24.3 42
CASP9 Cysteine-aspartic acid protease (caspase) 9, apoptosis-related cysteine peptidase 1p36.21 40
VEGFA Vascular endothelial growth factor A 6p12 40
FOXA1 Forkhead box A1 14q21.1 40
MET MET proto-oncogene, receptor tyrosine kinase 7q31 40
CYP3A5 Cytochrome P450, family 3, subfamily A, polypeptide 5 7q21.1 39
RASSF1 Ras association (RalGDS/AF-6) domain family member 1 3p21.3 39
PDLIM4 PDZ and LIM domain 4 5q31.1 38
MSR1 Macrophage scavenger receptor 1 8p22 38