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Table 2 List of Genes Associated with Prostate Cancer and Oxidative Stress. [50, 113]

From: Oxidative stress in prostate hyperplasia and carcinogenesis

Gene

Gene name

Location

Papers

KLK3

Kallikrein-related peptidase 3

19q13.41

3000

AR

Androgen receptor

Xq12

1221

MKI67

Marker of proliferation Ki-67

10q26.2

424

PTEN

Phosphatase and tensin homolog

10q23.3

376

TP53

Tumor protein p53

17p13.1

343

TMPRSS2

Transmembrane protease, serine 2

21q22.3

336

CTNNB1

Catenin (cadherin-associated protein), beta 1

3p21

312

BRCA1

Breast cancer 1, early onset

17q21

178

BRCA2

Breast cancer 2, early onset

13q12.3

156

PROC

Protein C (inactivator of coagulation factors Va and VIIIa)

2q13-q14

135

CDKN1A

Cyclin-dependent kinase inhibitor 1A (p21, Cip1)

6p21.2

125

NKX3-1

NK3 homeobox 1

8p21.2

120

SRD5A2

Steroid-5-alpha-reductase,

2p23

120

SRC

SRC proto-oncogene, non-receptor tyrosine kinase

20q12-q13

97

KITLG

KIT ligand

12q22

93

CDKN1B

Cyclin-dependent kinase inhibitor 1B (p27, Kip1)

12p13.1-p12

92

CD44

CD44 molecule (Indian blood group)

11p13

87

TGFB1

Transforming growth factor, beta 1

19q13.1

83

HIF1A

Hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)

14q23.2

82

CYP17A1

Cytochrome P450, family 17, subfamily A, polypeptide 1

10q24.3

82

PTGS2

Prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)

1q25.2-q25.3

81

PPARG

Peroxisome proliferator-activated receptor gamma

3p25

81

PCA3

Prostate cancer associated 3 (non-protein coding)

9q21.2

78

IGFBP3

Insulin-like growth factor binding protein 3

7p12.3

76

EZH2

Enhancer of zeste 2 polycomb repressive complex 2 subunit

7q35-q36

75

ETV1

ETS (E twenty-six) variant 1

7p21.3

73

GSTM1

Glutathione S-transferase mu 1

1p13.3

72

JUN

Jun proto-oncogene

1p32-p31

65

CAMP

Cathelicidin antimicrobial peptide

3p21.3

61

ELAC2

ElaC ribonuclease Z 2

17p11.2

56

SERPINB5

Serpin peptidase inhibitor, clade B (ovalbumin), member 5

18q21.33

54

CD82

CD82 molecule

11p11.2

50

AMACR

Alpha-methylacyl-CoA racemase

5p13

50

IGF1R

Insulin-like growth factor 1 receptor

15q26.3

49

IL10

Interleukin 10

1q31-q32

47

E2F1

E2F transcription factor 1

20q11.2

46

MSMB

Microseminoprotein, beta- (10q11.2)

10q11.2

45

TRPM2

Transient receptor potential cation channel, subfamily M, member 2

21q22.3

44

CYP3A4

Cytochrome P450, family 3, subfamily A, polypeptide 4

7q21.1

43

CLU

Clusterin

8p21-p12

43

PSCA

Prostate stem cell antigen

8q24.2

42

FOS

FBJ murine osteosarcoma viral oncogene homolog

14q24.3

42

CASP9

Cysteine-aspartic acid protease (caspase) 9, apoptosis-related cysteine peptidase

1p36.21

40

VEGFA

Vascular endothelial growth factor A

6p12

40

FOXA1

Forkhead box A1

14q21.1

40

MET

MET proto-oncogene, receptor tyrosine kinase

7q31

40

CYP3A5

Cytochrome P450, family 3, subfamily A, polypeptide 5

7q21.1

39

RASSF1

Ras association (RalGDS/AF-6) domain family member 1

3p21.3

39

PDLIM4

PDZ and LIM domain 4

5q31.1

38

MSR1

Macrophage scavenger receptor 1

8p22

38