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Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: Long non-coding RNA XIST regulates gastric cancer progression by acting as a molecular sponge of miR-101 to modulate EZH2 expression

Fig. 4

Regulation relationship between lncRNA XIST and miR-101. a Schematic representation of the predicted target site for miR-101 in lncRNA XIST. b Knockdown of lncRNA XIST increased miR-101 expression in SGC7901 cells (*P < 0.05). c Real-time PCR analysis confirmed the miR-101 ectopic expression and miR-101 inhibition in SGC7901 cells (*P < 0.05). d Ectopic miR-101 expression decreased lncRNA XIST expression while inhibition of miR-101 increased lncRNA XIST expression (*P < 0.05). e Luciferase reporter assay in human embryonic kidney (HEK) 293 T cells, co-transfected with the reporter plasmid (or the corresponding mutant reporter) and the indicated miRNAs. miR-101 significantly decreased the luciferase activity in XIST-wt but not in XIST-mt (*P < 0.05). f The expression of lncRNA XIST was inversely correlated with the expression level of miR-101 in gastric cancer tissues (*P < 0.05)

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