Table 1 Clinical and histological characteristics HNSCC patients in TCGA database
Characteristic | n (%) | AREG mRNA levela | p valueb |
|---|---|---|---|
Gender | |||
 Male | 284 (71) | 1249 | 0.48 |
 Female | 115 (29) | 1199 | |
Age | |||
  ≤ 49 | 68 (17) | 238.1 | 0.28 |
 50–59 | 112 (28) | 193.7 | |
 60–69 | 133 (33) | 193.1 | |
  ≥ 70 | 86 (22) | 188.8 | |
Tumor sites | |||
 Oral Cavity | 246 (62) | 1441 | <0.0001*** |
 Lip | 2 (1) | 129 | |
 Oropharynx | 55 (14) | 552 | |
 Larynx | 91 (23) | 972 | |
 Hypopharynx | 5 (1) | 1516 | |
Tumor pathological stage | |||
 I–II | 84 (21) | 972 | 0.08 |
 III–IV | 259 (65) | 1395 | |
 Missing | 56 (14) | 730 | |
Tumor pathological T | |||
 T1-T2 | 141 (35) | 1090 | 0.03* |
 T3-T4 | 207 (52) | 1402 | |
 Missing | 51 (13) | 780 | |
Tumor pathological N | |||
 N0 | 130 (33) | 1312 | 0.67 |
 N1-3 | 183 (46) | 1352 | |
 Missing | 86 (21) | 759 | |
Tumor histological grade | |||
 G1-2 | 284 (71) | 1296 | <0.001*** |
 G3-4 | 103 (26) | 1082 | |
 GX | 12 (3) | 369 | |
Smoking history | |||
 Smoker | 305 (76) | 1216 | 0.83 |
 Non-smoker | 84 (22) | 1170 | |
 Unknown | 10 (2) | 1482 | |
Alcohol history | |||
 Alcohol consumption | 273 (68) | 973 | 0.24 |
 No alcohol consumption | 119 (30) | 1309 | |
 Unknown | 7 (2) | 1517 | |
Human papillomavirus | |||
 Positive | 18 (4) | 55 | <0.001*** |
 Negative | 66 (17) | 807 | |
 Unknown | 315 (79) | 1391 | |