Skip to main content

Table 1 Clinical and histological characteristics HNSCC patients in TCGA database

From: Epidermal growth factor (EGF) receptor-ligand based molecular staging predicts prognosis in head and neck squamous cell carcinoma partly due to deregulated EGF- induced amphiregulin expression

Characteristic n (%) AREG mRNA levela p valueb
Gender
 Male 284 (71) 1249 0.48
 Female 115 (29) 1199
Age
  ≤ 49 68 (17) 238.1 0.28
 50–59 112 (28) 193.7
 60–69 133 (33) 193.1
  ≥ 70 86 (22) 188.8
Tumor sites
 Oral Cavity 246 (62) 1441 <0.0001***
 Lip 2 (1) 129
 Oropharynx 55 (14) 552
 Larynx 91 (23) 972
 Hypopharynx 5 (1) 1516
Tumor pathological stage
 I–II 84 (21) 972 0.08
 III–IV 259 (65) 1395
 Missing 56 (14) 730
Tumor pathological T
 T1-T2 141 (35) 1090 0.03*
 T3-T4 207 (52) 1402
 Missing 51 (13) 780
Tumor pathological N
 N0 130 (33) 1312 0.67
 N1-3 183 (46) 1352
 Missing 86 (21) 759
Tumor histological grade
 G1-2 284 (71) 1296 <0.001***
 G3-4 103 (26) 1082
 GX 12 (3) 369
Smoking history
 Smoker 305 (76) 1216 0.83
 Non-smoker 84 (22) 1170
 Unknown 10 (2) 1482
Alcohol history
 Alcohol consumption 273 (68) 973 0.24
 No alcohol consumption 119 (30) 1309
 Unknown 7 (2) 1517
Human papillomavirus
 Positive 18 (4) 55 <0.001***
 Negative 66 (17) 807
 Unknown 315 (79) 1391
  1. amRNA expression levels were measured as fragments per kilobase per million mapped reads (FPKM), medians were shown
  2. bGroup differences were compared using Wilcoxon rank-sum test or Kruskal-Willis test (*p < 0.05, ***p < 0.001)