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Fig. 2 | Journal of Experimental & Clinical Cancer Research

Fig. 2

From: TIMP1 is a prognostic marker for the progression and metastasis of colon cancer through FAK-PI3K/AKT and MAPK pathway

Fig. 2

TIMP1 expression and pathologic features in colorectal cancer specimens. a Immunohistochemical staining of TIMP1. TIMP1 was localized within the cytoplasm and overexpression in the tumor cells of colorectal cancer tissue. b Western blot analysis was performed to assess TIMP1 protein levels in 4 representative cases of colorectal cancer specimens. c The disease-free survival (DFS) and overall survival (OS) rates were estimated by the Kaplan–Meier method. Both the DFS rate and OS rate of patients with TIMP1 positive primary tumor were significantly lower than that of patients with TIMP1 negative primary tumor. d TIMP1 protein levels in colorectal cancer cell lines (scale bar = 40 μm)

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