Fig. 6

TIMP1 promotes CRC progression and metastasis in nude mice. a Representative Data showed that TIMP1-KD significantly inhabited tomor growth in nude mice xenograft. b-c Tumor volume and tumor weight was decreased in TIMP1-KD cells’ mice model. d Representative formation of lung metastases by tail-vein injection of scramble and HCT116/SW620–Luc2 cells in immunocompromised mice. Representative images of luciferase signals (Left panel). Normalized photon flux (Right panel). e-f HCT116/SW620-luc2 cells were injected into the tail vein of NOD/SCID mice, and followed by noninvasive bioluminescence imaging for 7 weeks