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Table 3 Multivariate Cox proportional hazards analysis for disease-free survival (DFS) and overall survival (OS)

From: TIMP1 is a prognostic marker for the progression and metastasis of colon cancer through FAK-PI3K/AKT and MAPK pathway

Variable

Multivariate analysis (DFS)

Multivariate analysis (OS)

P-value

HR (95%CI)

P-value

HR (95%CI)

AJCC stage (I/II vs. III/IV)

0.037*

2.621 (1.011–6.668)

0.029*

2.915 (1.113–7.634)

N stage (N0 vs. N1 + N2)

0.043*

2.354 (1.027–5.395)

0.033*

2.785 (1.086–7.141)

M stage (M0 vs. M1)

0.049*

3.649 (1.008–13.214)

0.035*

2.465 (1.067–5.696)

Vascular invasion (Yes vs. No)

0.038*

2.488 (1.051–5.891)

0.024*

2.945 (1.151–7.535)

TIMP1 expression (Negative vs. Positive)

0.027*

2.603 (1.115–6.077)

0.013*

2.907 (1.254–6.737)

  1. AJCC American Joint Committee on Cancer, HR hazard ratio, CI confidence interval
  2. *p < 0.05 indicates a significant association between the variables