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Fig. 3 | Journal of Experimental & Clinical Cancer Research

Fig. 3

From: Exosomes derived from HCC cells induce sorafenib resistance in hepatocellular carcinoma both in vivo and in vitro

Fig. 3

HCC cell-derived exosomes induce resistance to sorafenib in hepatoma carcinoma cells in vivo. a Tumors from mice treated with PBS (Control), sorafenib (Sora), sorafenib + LO2-exosomes (Sora + LO2 exo), sorafenib + MHCC-97 L-exosomes (Sora + 97 L exo), and sorafenib + MHCC-97H-exosomes (Sora + 97H exo) at the end of the experiment. b Tumor growth curves in mice treated with PBS (Control), sorafenib (Sora), sorafenib + LO2-exosomes (Sora + LO2 exo), sorafenib + MHCC-97 L-exosomes (Sora + 97 L exo), and sorafenib + MHCC-97H-exosomes (Sora + 97H exo) (n = 5, * P <0.05, ** P <0.01). Treatment was initiated when tumors reached a volume of 50–100 mm3 (15 days after subcutaneous injections of tumor cells). c The mean weight of the tumors from mice treated with PBS (Control), sorafenib (Sora), sorafenib + LO2-exosomes (Sora + LO2 exo), sorafenib + MHCC-97 L-exosomes (Sora + 97 L exo), and sorafenib + MHCC-97H-exosomes (Sora + 97H exo) at the end of the experiment (n = 5, * P <0.05, ** P <0.01)

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