Fig. 5

HCC cell-derived exosomes reverse sorafenib-induced apoptosis in hepatoma carcinoma cells in vitro. a Flow cytometric analyses of apoptotic cells ex vivo. The SMMC-7721 cells were exposed to sorafenib alone or sorafenib and exosomes for 48 h, collected and subjected to Annexin V/PI double staining, followed by FACS analyses. For each assay, 10,000 cells were analyzed. b The quantitative data are presented as the mean ± SD of triplicate experiments (* P <0.05)