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Fig. 6 | Journal of Experimental & Clinical Cancer Research

Fig. 6

From: LCL161 increases paclitaxel-induced apoptosis by degrading cIAP1 and cIAP2 in NSCLC

Fig. 6

The knockdown of cIAP1 and cIAP2 increases paclitaxel-induced cell apoptosis. a A549 and H460 cells were transfected with siRNA control or siRNA cIAP1,2 for 48 h. The expression of cIAP1,2 was assessed by western blotting. β-Actin was used as a loading control. b The bar graphs represent the mean ± SD of cIAP1 or cIAP2/β-actin. c After transfection with siRNA for 48 h, the cells were treated for 48 h with 10 μM paclitaxel, and their apoptosis was detected by Annexin V/PI staining. Data are represented as mean ± SD; *P < 0.05; **P < 0.01; ***P < 0.001

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