From: Trends and advances in tumor immunology and lung cancer immunotherapy
Target | Agent/Ab type | Pt No. | Phase | Results |
---|---|---|---|---|
CTLA-4 | Ipilimumab IgG1 | 204 | II | Phased ipilimumab: irPFS: 5.7Â months; PFS: 5.1Â months; Median OS: 12.2Â months. Concurrent ipilimumab: irPFS: 5.5Â months; PFS: 4.1Â months; Median OS: 9.7Â months. Control: irPFS: 4.6Â months; PFS: 4.2Â months; Median OS: 8.3Â months [90]. |
Tremelimumab IgG2 | 87 | II | ORR: 4.8Â %; PFS: 20.9Â % vs. 14.3Â % with supportive care [91]. | |
29 | II | Disease control: 31Â % of patients, Median PFS: 6.2Â months; Median OS: 10.7Â months [92]. | ||
PD-1 | Nivolumab IgG4 | 129 | I | Median OS across doses: 9.9Â months; Median OS: 14.9Â months at 3Â mg/kg vs 9.2 at 1&10Â mg/kg; ORR: 3 (1Â mg/kg), 24 (3Â mg/kg), and 20Â % (10Â mg/kg). 1-year OS rates at 3Â mg/kg: 56Â % [99]. |
117 | II | PR: 14.5Â % of patients; Stable disease: 26Â % of patients; Median duration: 6Â months; Median OS: 8.2Â months; 1-year OS rates: 40.8Â % [100]. | ||
582 | III | Median OS: 12.2Â months vs 9.4Â months with docetaxel; ORR: 19.2Â % vs 12.4Â % with docetaxel. Median DOR: 17.1Â months vs 5.6Â months docetaxel [101]. | ||
Pembrolizumab IgG4 | 495 | I | ORR: 19.4Â %; Median DOR: 12.5Â months; Median PFS: 3.7 Months; Median OS: 12Â months [102]. | |
PD-L1 | Atezolizumab IgG1 | 37 | I | ORR: 24Â %; 24-week PFS: 48Â % [106]. |
667 | II | ORR: 19Â % when atezolizumab used as a first-line therapy vs 17Â % when it was a second-line or subsequent therapy [107]. | ||
277 | II | OS: 12.6Â months with atezolizumab vs 9.7 with docetaxel; PFS: 2.7Â months with atezolizumab vs 3Â months with docetaxel; OR: 14.3 with atezolizumab vs 7.2 with docetaxel [108]. | ||
BMS-936559 IgG4 | 75 | I | ORR: 10 %; Stable disease ≥24 weeks: 12 %; PFS at 24 weeks: 31 % [109]. | |
MEDI4736 IgG1 | 200 | I/II | ORR: 16Â %; Disease control rate at 12Â weeks: 42Â % [110]. |