Fig. 4

TRIM62 impedes growth and metastasis of cervical cancer in vivo. Effect of TRIM62 on tumor growth and metastasis were investigated in nude mouse xenograft model, which was built by injecting stable CC cells (SiHa-NC, SiHa-TRIM62, HeLa-NC and HeLa-TRIM62). **, P < 0.01; ***, P < 0.001. a A representative picture of tumors originated from nude mice, which had subcutaneously inoculated with stable CC cells as described above for 30 days. b Diagrams showed the calculation of the tumor weight of TRIM62 overexpressed groups (SiHa-TRIM62 and HeLa-TRIM62) compared with that of the corresponding control groups (SiHa-NC and HeLa-NC) (n = 6). c Subcutaneous tumor growth curves of each group were displayed (n = 6). d Typical H&E images of pulmonary metastatic foci in control groups and normal pulmonary tissues in TRIM62 overexpressed groups were shown, which indicating the metastatic capacity was decreased on TRIM62 overexpressed groups. Original magnification: ×100, ×200 and × 400. e The diagrams showed the percentages of mice with or without metastatic foci in the lungs (n = 6)