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Table 3 Univariate and Multivariate Analysis of Factors Associated with Overall Survival and Disease-Free Survival in Validation Cohort

From: Tripartite motif containing 62 is a novel prognostic marker and suppresses tumor metastasis via c-Jun/Slug signaling-mediated epithelial-mesenchymal transition in cervical cancer

Clinicopathologic Variable Total OS DFS
Univariate Multivariate Analysis Univariate Multivariate Analysis
P RR (95 % CI) P P RR (95 % CI) P
Age(years)
42 44       
  > 42 37 0.682 n.a. n.a. 0.726 n.a. n.a.
FIGO stage
 Ia2 11   1    1  
 Ib1 39       
 Ib2 14       
 IIa1 7       
 IIa2 10 <0.001 1.546(1.082–2.211) 0.017 <0.001 1.575(1.102–2.250) 0.013
Tumor size(cm)
4 54       
  > 4 27 0.191 n.a. n.a. 0.210 n.a. n.a.
Pathologic types
 Squamous cell carcinoma 53       
 Adenocarcinoma 28 0.933 n.a. n.a. 0.908 n.a. n.a.
Differentiation grade
 Well 7       
 Moderate 36       
 Poor 38 0.105 n.a. n.a. 0.115 n.a. n.a.
Stromal invasion
  < 1/2 50   1    1  
1/2 31 0.020 1.900(0.763–4.734) 0.168 0.024 1.819(0.735–4.502) 0.196
Lymphovascular space invasion
 Yes 11       
 No 70 0.122 n.a. n.a. 0.182 n.a. n.a.
Pelvic-lymph node metastasis
 Yes 14   1    1  
 No 67 0.016 2.098(0.821–5.358) 0.122 0.026 1.775(0.697–4.518) 0.229
Vaginal involvement
 Yes 3       
 No 78 0.769 n.a. n.a. 0.662 n.a. n.a.
Parametrial infiltration
 Yes 2       
 No 79 0.218 n.a. n.a. 0.316 n.a. n.a.
TRIM62
 low 48   1    1  
 high 33 0.006 0.209(0.048–0.917) 0.038 0.006 0.206(0.047–0.902) 0.036
  1. Abbreviations: n.a. Not application, FIGO the International Federation of Gynecology and Obstetrics; The bold number inside the table reflected P < 0.05