Fig. 3From: Leptin promotes epithelial-mesenchymal transition of breast cancer via the upregulation of pyruvate kinase M2PKM2-siRNA abolished leptin-induced epithelial-mesenchymal transition in breast cancer cells. PKM2-siRNA treatment of MCF-7 and SK-BR-3 cells prior to 200 ng/mL leptin exposure decreased leptin-induced migration (a) and invasion (b–d) (P < 0.05). (e) PKM2-siRNA abolished leptin-induced downregulation of E-cadherin and upregulation of vimentin, fibronectin and Twist in MCF-7 and SK-BR-3 cells (P < 0.05)Back to article page