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Fig. 5 | Journal of Experimental & Clinical Cancer Research

Fig. 5

From: Hepatitis B virus X protein promotes interleukin-7 receptor expression via NF-κB and Notch1 pathway to facilitate proliferation and migration of hepatitis B virus-related hepatoma cells

Fig. 5

IL-7 gene expression and role of IL-7 in intracellular pathways and molecules in HBX-positive cells. a The expression of IL-7 in HepG2 and HepG2.215 cells detected by RT-PCR. b The expression of IL-7gene in hepatoma cells detected by RT-PCR after transfection with pUC-18 plasmid, pUC-18-HBV1.2 plasmid, and pUC-18-HBV1.2-HBX plasmid for 48 h. c The expression of IL-7 genes in hepatoma cells stably transfected with HBX. d and e The role of NF-κB and Notch 1 pathways in HBX-mediated upregulation of IL-7 in hepatoma cells. f The role of IL-7R in the IL-7-mediated activation of intracellular signaling pathways in HBX-positive cells (10 ng/mL). g The effect of IL-7R on IL-7-induced expression of associated molecules in HBX-positive cells

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