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Fig. 1 | Journal of Experimental & Clinical Cancer Research

Fig. 1

From: Efficacy and safety of aflibercept in in vitro and in vivo models of retinoblastoma

Fig. 1

Tumor volume and weight changes in the xenotransplantation model. a Representative macroscopic appearance of the xenotransplantation model 4 weeks after injection of Y-79 cells. Tumors were smaller in aflibercept-treated mice (n = 21) compared with those in saline-injected group (n = 21). b Body weight changes in the xenotransplantation model. Four weeks after Y-79 cell injection, body weights were not different between the two groups (c) Tumor volume changes in the xenotransplantation model. Whereas tumor volume significantly increased in the saline-injected group (# P < 0.005, ## P < 0.001), it remained unchanged in the aflibercept (25 mg/kg) treatment group. d Tumor weight changes in the xenotransplantation model. Tumor weights in the saline-injected group were also significantly heavier compared to those in the aflibercept treatment group (* P < 0.05)

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