Fig. 2

Aflibercept treatment suppresses tumor angiogenesis in a xenotransplantation model. a H&E-stained tumor tissue sections. Retinoblastoma cell density was reduced in the aflibercept treatment group compared with that in the saline-injected group. Substantially fewer vascular endothelial cells were detected in the aflibercept-treated group. b Representative lectin staining (green) of microvessels in tumor sections. Microvascular density in the aflibercept group was significantly lower than that in the saline-injected group. c Quantification of microvascular density (*P < 0.05). Original magnification, ×200; scale bar, 200 μm