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Fig. 6 | Journal of Experimental & Clinical Cancer Research

Fig. 6

From: Efficacy and safety of aflibercept in in vitro and in vivo models of retinoblastoma

Fig. 6

Effect of aflibercept on proliferation of HUVECs co-cultured with Y-79 or WERI-Rb-1 cells. a Fluorescence photomicrographs of DAPI staining (blue) in HUVEC co-cultures. Image showing HUVECs alone or HUVECs co-cultured with Y-79, with or without treatment with 1 mg/ml aflibercept. b Quantification of cell number. The number of HUVECs was increased by co-culture with Y-79 cells and attenuated by treatment with aflibercept (n = 4, * P < 0.05). c Fluorescence photomicrographs of DAPI staining (blue) in HUVEC co-cultures. Image showing HUVECs alone or HUVECs co-cultured with WERI-Rb-1, with or without treatment with 1 mg/ml aflibercept. d Quantification of cell number. The number of HUVECs was increased by co-culture with WERI-Rb-1 cells and attenuated by treatment with aflibercept (n = 4, ## P < 0.001, * P < 0.05). Original magnification, ×400; scale bar, 100 μm

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