Fig. 2From: Signalling pathways in UHRF1-dependent regulation of tumor suppressor genes in cancerSchematic model of the role of miRNA in UHRF1 regulation in cancer cells. Several miRNAs act as tumor-suppressor by binding to the 3′-untranslated region (3′-UTR) of mRNA UHRF1 leading to its degradation. TQ increases the expression of miR-34a which leads to upregulation of p53 in wild type p53 cancer cells or p73 in p53-mutated cancer cells with subsequent UHRF1 inhibition. UHRF1 downregulation results in the reactivation of others TSGs including p16 INK4A, BRCA1, PPARG and KiSS1 conducting to cell proliferation inhibition and apoptosisBack to article page