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Table 2 Overview of architectures of 8 viral-cellular junctions

From: HPV16 integration probably contributes to cervical oncogenesis through interrupting tumor suppressor genes and inducing chromosome instability

Junction ID

Type

Left element location

Middle element location

Right element location

Overlapping

S1-2:J-01

Type 2

HPV16 E1(211 bp)

NA

chr3:175701251-175701313 (63 bp) NAALADL2

Left & Right: No overlapping

S2-25:J-03

Type 1

HPV16 E1(122 bp)

chr9:125080078-125080338(261 bp) SCAI

chr4:148216738-148216850 (159 bp) NR3C2

Left & Middle: GATGCA

Middle & Right: GATC

S2-25:J-04

Type 1

HPV16 E1(185 bp)

chr17:30708288-30708380(93 bp)

chr1:165472779-165473100(322 bp)

Left &Middle: No overlapping

Middle & Right: AGATC

C3-64:J-05

Type 2

HPV16 E2(325 bp)

NA

chr3:124457727-124457915 (189 bp) KALRN

Left & Right: AA

C4-77:J-06

Type 2

chr4:185352615-185352687 SNX25(72 bp)

NA

HPV16 L1(310 bp)

Left & Right: No overlapping

C5-87:J-07

Type 2

chr22:34824077-34824170(93 bp)

NA

HPV16 L1(224 bp)

Left & Right: CAATA

C5-87:J-08

Type 1

chr22:34819634-3481983 (201 bp)

chrX:109333446-109333511(66 bp)

HPV16 E5 (299 bp)

Left & Middle: GTGG

Middle & Right: GTGTT

S6-95:J-09

Type 2

HPV16 E1(239 bp)

NA

chr16:82782336-82782494 (159 bp) CDH13

Left & Right: CTGCAA

  1. Each viral-cellular junction was assigned an unique ID. 8 junctions were divided into 2 types according to the architecture of viral-cellular junctions. Type 1: 3-element junction with the architecture of virus-human-human or human-human-virus. Type 2: 2-element junction with the architecture of virus-human or human-virus. The origin of each elements were shown in column 3, 4 and 5 respectively. The overlapping between every two elements were shown in column 6. NA, not available