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Table 2 Overview of architectures of 8 viral-cellular junctions

From: HPV16 integration probably contributes to cervical oncogenesis through interrupting tumor suppressor genes and inducing chromosome instability

Junction ID Type Left element location Middle element location Right element location Overlapping
S1-2:J-01 Type 2 HPV16 E1(211 bp) NA chr3:175701251-175701313 (63 bp) NAALADL2 Left & Right: No overlapping
S2-25:J-03 Type 1 HPV16 E1(122 bp) chr9:125080078-125080338(261 bp) SCAI chr4:148216738-148216850 (159 bp) NR3C2 Left & Middle: GATGCA
Middle & Right: GATC
S2-25:J-04 Type 1 HPV16 E1(185 bp) chr17:30708288-30708380(93 bp) chr1:165472779-165473100(322 bp) Left &Middle: No overlapping
Middle & Right: AGATC
C3-64:J-05 Type 2 HPV16 E2(325 bp) NA chr3:124457727-124457915 (189 bp) KALRN Left & Right: AA
C4-77:J-06 Type 2 chr4:185352615-185352687 SNX25(72 bp) NA HPV16 L1(310 bp) Left & Right: No overlapping
C5-87:J-07 Type 2 chr22:34824077-34824170(93 bp) NA HPV16 L1(224 bp) Left & Right: CAATA
C5-87:J-08 Type 1 chr22:34819634-3481983 (201 bp) chrX:109333446-109333511(66 bp) HPV16 E5 (299 bp) Left & Middle: GTGG
Middle & Right: GTGTT
S6-95:J-09 Type 2 HPV16 E1(239 bp) NA chr16:82782336-82782494 (159 bp) CDH13 Left & Right: CTGCAA
  1. Each viral-cellular junction was assigned an unique ID. 8 junctions were divided into 2 types according to the architecture of viral-cellular junctions. Type 1: 3-element junction with the architecture of virus-human-human or human-human-virus. Type 2: 2-element junction with the architecture of virus-human or human-virus. The origin of each elements were shown in column 3, 4 and 5 respectively. The overlapping between every two elements were shown in column 6. NA, not available