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Table 5 Overview of cancer related genes closely linked to HPV integration sites documented in Dr.VIS v2.0 database [72]

From: HPV16 integration probably contributes to cervical oncogenesis through interrupting tumor suppressor genes and inducing chromosome instability

ID Method Disease Subtype Cytoband Nearest gene
DRVIS03185 PCR HNC HPV16 1q25 TNFSF4
DRVIS03195 Exome-Seq CC HPV56 3q28 TP63
DRVIS03198 Mapping CC HPV16 1p36.32 TP73
DRVIS02845 RS-PCR CC HPV16 4q13.3 RASSF6
DRVIS00089 DIPS-PCR CC HPV16 2q21.2 ARHGEF4
DRVIS00246 DIPS-PCR CC HPV16 16q24 CDH13
  1. The ID of integration events in Dr.VIS v2.0 database, methods for the detection of viral integration, disease associated with samples, HPV subtype and integration locations were shown in column 1, 2, 3, 4, 5 and 6 respectively. HNC, head and neck cancer; CC, cervical carcinoma; Exome-Seq, Exome sequencing; DIPS-PCR, detection of integrated papillomavirus sequences by ligation-mediated PCR; RS-PCR, RNA Template-Specific PCR; Mapping, mapping analysis. TNFSF4 (tumor necrosis factor superfamily member 4), TP63 (tumor protein p63), TP73 (tumor protein p73), ARHGEF4 (Rho guanine nucleotide exchange factor 4), CDH13 (cadherin 13), RASSF6 (Ras association domain family member 6)