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Fig. 5 | Journal of Experimental & Clinical Cancer Research

Fig. 5

From: Inhibitory effects of lapachol on rat C6 glioma in vitro and in vivo by targeting DNA topoisomerase I and topoisomerase II

Fig. 5

Effects of different concentrations of lapachol on apoptosis and DNA damage of C6 cells. a Hoechst 33258 staining for C6 glioma cells after being treated with control (a), 1 μM lapachol (b), 5 μM lapachol (c), and 10 μM lapachol (d). riginal magnification: ×200. b Annexin V-FITC/PI staining for apoptosis rates of cells after being treated with control (a), 1 μM lapachol (b), 5 μM lapachol (c), and 10 μM lapachol (d). c Comet assay result of cells after being treated with control (a), 1 μM lapachol (b), 5 μM lapachol (c), and 10 μM lapachol (d). Original magnification: ×200. d Tail intensity of C6 cells in the comet assay. Mean ± SD of three independent experiments. * P < 0.05 compared with the control

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