Fig. 6

Effects of lapachol on TOP I and TOP II activities by the conversion of supercoiled pBR322 DNA to its relaxed form. TOP I and TOP II drug screening kits were used. a TOP I inhibition assay result by lapachol; b TOP II inhibition assay result by lapachol. The known TOP I inhibitor camptothecin and TOP II poisons etoposide were used as positive controls