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Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: Sirtuins in metabolism, DNA repair and cancer

Fig. 4

Nuclear sirtuins regulate genomic stability and their roles in the DDR are summarized. SIRT1 is implicated in diverse DNA repair pathways. SIRT1 promotes HR DNA repair by deacetylating WRN, a DNA helicase. It also regulates NHEJ and NER through Ku70 and XPA and XPC after genotoxic stimuli. Like SIRT1, SIRT6 modulates DNA repair pathways at multiple layers. SIRT6 affects BER in a PARP1-depdendent manner and recruits DNA-PK to promote NHEJ. It interacts with two major BER enzymes MYH and APE1 as well. Most recent study uncovered SIRT7 induce NHEJ by recruiting repair factor 53BP1. XPA and XPC, xeroderma pigmentosum A and C; APE1,Apurinic/apyrimidinic endonuclease 1; DNA-PK,DNA-dependent protein kinase

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